BIOMARKERS

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Technology, BIOMARKERS, LIFESTYLE, MEDICINE 3.0

DAYHOFF TECHNOLOGIES RANKED BEST MICROBIOME TEST

Scientists recognize Dayhoff as most accurate microbiome test using triple-sampling, immediate freezing, and research-grade shotgun metagenomics—setting new industry standard for consumer testing. DALLAS, TX – September 29, 2025 – Dayhoff Technologies, a clinical-grade microbiome testing company, today announced its consumer microbiome test has been recognized by leading microbiome scientists as delivering the most clinically accurate representation of gut microbiome composition among all retail testing options currently available in North America. The peer evaluation, conducted in early 2025 by independent microbiome researchers, compared Dayhoff’s proprietary triple-sampling methodology against single-sample approaches used by competitors of other major consumer testing services. Scientists cited Dayhoff’s unique combination of multiple sampling points, frozen chain-of-custody protocols, and high-depth shotgun metagenomics as setting a new standard for clinical accuracy in direct-to-consumer microbiome analysis. “While other companies rely on single-point sampling that can miss microbial diversity due to temporal variations, our triple-sampling approach captures a comprehensive view of the microbiome ecosystem,” said Roozbeh Ebbadi, CEO of Dayhoff Technologies. “This recognition validates our commitment to bringing research-grade accuracy to consumer health testing.” Revolutionary Triple-Sample Methodology Addresses Industry’s Accuracy Challenge The global microbiome testing market, projected to reach $1.9 billion by 2028 according to Grand View Research¹, has faced persistent challenges with result reliability and clinical utility. Studies published in Nature Microbiology have shown that single-sample tests can vary by up to 50% day-to-day due to natural microbiome fluctuations². Dayhoff’s CLIA-certified testing protocol addresses these limitations through: “The microbiome field has struggled with standardization and reproducibility. Dayhoff’s approach mirrors the protocols we use in clinical research trials,” noted Dr. Armstrong. “The combination of multiple sampling points and frozen preservation is essential for accurate clinical interpretation.” Advanced Computing Platform Accelerates Precision Medicine Applications Dayhoff’s patented analysis platform, originally developed for academic research institutions, processes microbiome data using next-generation GPU acceleration to complete parts of its analysis. This computational infrastructure enables processing speeds up to 10 times faster than traditional methods while maintaining the analytical depth required for clinical applications. The platform’s capabilities have attracted attention from precision medicine researchers studying connections between gut health and chronic conditions including inflammatory bowel disease, metabolic disorders, and mental health conditions. Recent research published in Cell has demonstrated that accurate microbiome profiling can predict treatment responses in up to 60% of IBS patients⁴. Accessibility Meets Clinical Standards Despite its clinical-grade methodology, Dayhoff has maintained consumer accessibility with HSA eligibility for insurance coverage and availability throughout North America. This positions the company uniquely in a market where clinical accuracy often comes at prohibitive costs or requires physician ordering. “We believe everyone deserves access to clinically accurate health information,” added Mr. Ebbadi. “Making our test HSA-eligible removes some financial barriers while maintaining the quality standards healthcare providers expect.” The recognition comes as consumer interest in microbiome testing surges, with Google searches for “gut microbiome test” increasing 250% over the past two years⁵. However, regulatory scrutiny has also intensified, with the FDA issuing guidance on microbiome testing accuracy standards expected in late 2025. About Dayhoff Technologies Founded in 2021 and headquartered in Dallas, Texas, Dayhoff Technologies is pioneering clinical-grade microbiome testing for consumers. The company’s CLIA-certified laboratory and patented analysis platform deliver research-quality microbiome insights directly to consumers, supporting personalized health optimization through precision microbiome analysis. For more information, visit www.dayhoff.ai Forward-Looking Statements This news release contains forward-looking statements and forward-looking information within the meaning of applicable securities laws. The use of any of the words “expect”, “anticipate”, “continue”, “estimate”, “objective”, “may”, “will”, “project”, “should”, “believe”, “plans”, “intends” and similar expressions are intended to identify forward-looking information or statements. The forward-looking statements and information are based on certain key expectations and assumptions made by the Company. Although the Company believes that the expectations and assumptions on which such forward-looking statements and information are based are reasonable, undue reliance should not be placed on the forward-looking statements and information because the Company can give no assurance that they will prove to be correct. References: Media ContactCompany Name: Dayhoff TechnologiesContact Person: InderEmail: Send EmailCountry: United StatesWebsite: https://www.dayhoff.ai/

BIOMARKERS

Female Hormones: DAYHOFF Guide to Balanced Health

Women’s bodies are biologically brilliant and uniquely complex. At the center of this complexity? Hormones—powerful chemical messengers that influence everything from your mood and metabolism to fertility and focus. Yet despite their crucial role, hormonal health is often misunderstood, mismanaged, or ignored altogether. At DAYHOFF, we believe every woman deserves personalized, science-based insights to understand and optimize her hormonal health. In this guide, we break down the essentials of female hormones, common signs of imbalance, and how modern biomarker testing can help you take control. Key Takeaways Why Hormonal Health Feels So Overwhelming Many women today wear multiple hats—caregivers, professionals, planners, and health advocates—not just for themselves, but for their families too. With so many roles and so much conflicting health advice out there, staying on top of your own hormonal health can feel like one more task in an already full schedule. Hormonal health shouldn’t feel like a guessing game. It should feel like a science-backed roadmap—and DAYHOFF is here to help make that a reality. How Hormones Impact Women’s Health Hormones are more than just reproductive regulators—they are full-body messengers that affect your: When hormones are in balance, women feel strong, clear-headed, and energized. When they’re not, the effects ripple throughout the body and mind. Meet Your Hormonal Power Players Understanding the major hormones at work in your body can help you better interpret your symptoms and health patterns: Signs Your Hormones May Be Out of Sync Hormonal imbalances can look different for every woman. Common red flags include: If any of these feel familiar, your body may be signalling that your hormones need attention. The Power of Biomarker Testing With DAYHOFF’s biomarker testing, we bring scientific precision to your hormonal health journey. Our tests analyze key hormone levels through a simple home or in-office blood draw, offering actionable insights that allow you to: Key Biomarkers for Female Hormonal Health Here are a few of the essential biomarkers we track at DAYHOFF to support women’s hormonal optimization: Taking Charge of Your Hormonal Health Whether you’re navigating puberty, trying to conceive, managing perimenopause, or simply optimizing daily wellness, here are a few foundational steps: You Deserve Clarity and Control Hormonal health shouldn’t feel mysterious or frustrating. With the right tools and guidance, it can be empowering. Whether you’re dealing with brain fog, cycle irregularities, or just want to better understand your body, DAYHOFF is here to bring clarity to your health journey. Ready to Decode Your Hormones? At DAYHOFF, we offer comprehensive biomarker testing that includes hormonal panels tailored for women’s health. Through convenient home or in-office blood draws, we analyze over 50+ healthspan-related biomarkers and deliver personalized health reports with actionable insights—no guesswork, just science-backed data. Our approach combines expert oversight, modern diagnostics, and concierge care—all designed to help you live stronger, longer, and with greater hormonal harmony. DAYHOFF: Your Partner in Personalized, Precision Health

Dayhoff does not diagnose, treat, or prevent diseases. All tests and analyses are for informational purposes only and should be reviewed with a licensed medical professional where applicable.

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