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Dayhoff microbiome Age Research Edition

Dayhoff is launching a new study to investigate how a prebiotic supplement influences the adult gut microbiome. By participating, you’ll contribute to understanding the potential effects of human milk oligosaccharides (HMOs) on gut health. This study is conducted in collaboration with Layer Origin, and we plan to publish the findings upon completion.
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Exploring the Effects of HMO Intake in Adults

Emerging research suggests that Human Milk Oligosaccharides (HMOs) may enhance gut health in adults by promoting the growth of beneficial bacteria. Originally studied in infants, HMOs are known to selectively support strains like Bifidobacterium, helping to establish a balanced gut microbiome and support immune system development.

Recent studies indicate that similar benefits may extend to adults. Supplementation with HMOs has been associated with increased levels of Bifidobacteria and elevated production of Short Chain Fatty Acids (SCFAs)—key compounds known to strengthen the gut barrier and reduce inflammation.

Study Objective:
This study aims to evaluate the impact of daily HMO supplementation on the adult gut microbiome. Participants will be randomly assigned to receive either an HMO supplement or a placebo once daily for 30 days. Gut microbiome samples will be collected at the start and end of the study to assess changes.

Support Gut Health Research with Dayhoff

Gain personalized insights through gut microbiome testing and contribute to research on how prebiotic supplements affect digestive health. Join Dayhoff in advancing our understanding of prebiotic supplements and their role in shaping the adult gut microbiome.
Study completed

Am I Eligible to Participate?

Inclusion Criteria

  • You may be eligible to participate if you are between 18 and 40 years of age.

  • Participants must also be residents of the United States or Canada.

Exclusion Criteria

  • You have taken probiotic or prebiotic supplements in the past 6 months, including: Probiotic powders or capsules Beverages or supplements with added probiotics Multivitamins containing probiotics (Note: Naturally fermented foods such as yogurt, kefir, and kombucha are permitted.)

  • You have taken oral or intravenous antibiotics in the past 8 weeks

  • You have any of the following existing health conditions: Gastrointestinal disorders (e.g., IBS, IBD, Celiac disease) Immune or autoimmune conditions, including: Severe Combined Immunodeficiency (SCID) Human Immunodeficiency Virus (HIV)

  • You have received results from an at-home microbiome stool test within the past 6 months (Excludes clinical lab tests such as cultures or pathogen screenings)

  • You are pregnant, breastfeeding, or planning to conceive during the study period

  • You are lactose intolerant or have a dairy allergy

  • You intend to use any other prebiotic or probiotic supplements or complete an at-home microbiome test during the study

  • You plan to make significant changes to your diet over the course of the study

How to Join the Study

If you’re interested in participating, please start by completing a brief survey. If you qualify, you’ll receive a special link to purchase your gut microbiome test at a discounted rate.
Study completed

About Dayhoff

Driving Personalized Medicine with Next-Generation Research

Dayhoff integrates cutting-edge data science, deep learning, and a robust bioinformatics repository to advance personalized medicine. From families seeking actionable health insights to research labs exploring intricate datasets, our patented technology and expert partnerships deliver transformative results.

How does the Research Edition work?

  • 1 Apply for the Study

Complete the qualification survey using the button on this page to find out if you’re eligible.
Interested participants will be asked to provide basic information such as age and probiotic use, and to review a checklist for any relevant health conditions via email. If eligible, a clinical coordinator will connect with you virtually to complete the enrollment process and guide you through signing the consent forms.

Both gut samples can be collected at home using our easy swab method. A prepaid return envelope will be included in your kit for mailing the samples back.

You’ll also complete a health history questionnaire and a follow-up survey after sampling.

Processed in a CLIA-certified lab using proprietary technology, Dayhoff’s gut health test delivers strain-level accuracy and a comprehensive profile of all microbes in the gut microbiome—including bacteria, fungi, viruses, parasites, and archaea. Results are typically available within 4–5 weeks.

  • 2 Consent to the Study
This study is open to residents of the U.S. and Canada, aged 18 to 40, who are not pregnant, breastfeeding, or trying to conceive.
  • 3 Receive Gut Test Results at the Completion of the Study

At the end of the study, you’ll receive a detailed gut health report, including a personalized expert note reviewed by Dayhoff’s microbiome team.
Dayhoff also offers actionable, evidence-based recommendations to help adults understand their gut health and address potential imbalances.

Please note: The gut microbiome report and action plan are part of Dayhoff’s standard Gut Test product and are not directly linked to the research study itself.

Participants who complete the study and all required surveys will be eligible to receive $100 in compensation.

How do we look at the microbiome?

High-Resolution Analysis

We leverage deep shotgun metagenomic sequencing—the gold standard in microbiome science—for a detailed and dependable analysis that empowers confident, informed decisions.

Breakthrough Insights

Our functional profiling reveals not just which microbes are present and in what quantities, but also what roles they’re playing in your body.

Targeted Recommendations

Using strain-level precision, we identify specific microbes, track their transfer, assess probiotic impact, and deliver science-backed, personalized suggestions.

Privacy you can trust

Your personal data is always secure with us. We never sell your information, and all data is encrypted using industry-leading security protocols to ensure your complete privacy.

Processed in certified labs

Your samples are analyzed in a CLIA- and CAP-certified U.S. laboratory, ensuring accurate, reliable, and timely results you can trust.

Created in collaboration with leading experts in early-life microbiome health

Dr. David Song, MD

Chief Medical Officer
Integrative Pediatrician and Pediatric
Functional Medicine Expert
Founder, Healthy Kids Happy Kids

Dr. David Song, MD

Chief Medical Officer
Integrative Pediatrician and Pediatric
Functional Medicine Expert
Founder, Healthy Kids Happy Kids

Dr. David Song, MD

Chief Medical Officer
Integrative Pediatrician and Pediatric
Functional Medicine Expert
Founder, Healthy Kids Happy Kids

Dr. David Song, MD

Chief Medical Officer
Integrative Pediatrician and Pediatric
Functional Medicine Expert
Founder, Healthy Kids Happy Kids

Dr. David Song, MD

Chief Medical Officer
Integrative Pediatrician and Pediatric
Functional Medicine Expert
Founder, Healthy Kids Happy Kids

Dr. David Song, MD

Chief Medical Officer
Integrative Pediatrician and Pediatric
Functional Medicine Expert
Founder, Healthy Kids Happy Kids

Interested in Joining?

If you’d like to participate, please complete the survey. Eligible individuals will be contacted by the study coordinator to review consent and complete enrollment.
Study completed

Have Questions? We’ve Got Answers

Dayhoff does not diagnose, treat, or prevent diseases. All tests and analyses are for informational purposes only and should be reviewed with a licensed medical professional where applicable.

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